The retailer response to GLP-1

Published on
April 30, 2025
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The retailer response to GLP-1 supplements: How the Vitamin Shoppe is leading the way

As the GLP-1 landscape continues to skyrocket, we’re seeing more and more companion products emerging to meet the needs of consumers using GLP-1. We spoke about this recently and how GPL-1 is influencing the nutrition industry; today we’re looking at a retailer’s response to it all. 

Because what started as niche products from independent brands has now gained so much traction that major US retailers are starting to enter the space with their own GLP-1 support supplements. 

And leading the charge? The Vitamin Shoppe. 

The Vitamin Shoppe’s Whole Health RX: a dedicated GLP-1 supplement line

The Vitamin Shoppe recently launched its Whole Health RX range, a comprehensive line of supplements specifically designed to complement GLP-1 medications and promote a more holistic, sustainable approach to weight management. 

The range offers products that support nutritional balance, gut health, metabolic function, and sustainable weight management, all key areas impacted by GLP-1 therapies.

Let’s take a look at what’s included.

Whole Health RX product line up

1. Women’s Multivitamin

Formulated to address nutritional deficiencies commonly associated with using GLP-1, this multivitamin supports immune, muscle, bone, and cardiovascular health. It includes 24 essential vitamins and minerals.

2. Men’s Multivitamin

Similar to the women’s formula but optimised for male nutrient needs, this multivitamin promotes overall health and helps fill nutritional gaps for men on GLP-1 medications.

3. Synbiotic

Containing prebiotics, probiotics and postbiotics, this supplement supports gut barrier function, digestion, and encourages the growth of akkermansia, a beneficial gut bacteria. 

4. Fibre 

Designed to promote digestive regularity, regulate appetite, and support natural GLP-1 activity, this fibre supplement helps users feel fuller longer while maintaining gut health.

5. Nutrient Powder

A comprehensive powder designed to fill nutritional gaps during GLP-1 use while boosting digestive, immune and metabolic health.

6. Protein 

This supplement helps preserve lean muscle mass and supports skin hydration and elasticity, two areas often overlooked during weight loss.

Why it matters: GLP-1 is reshaping the wellness industry

Beyond the products themselves, the launch of a GLP-1 specific range by a national retailer like The Vitamin Shoppe is a clear sign of just how profoundly GLP-1 is influencing the industry. 

With the growing demand for GLP-1 companion products, it’s only a matter of time before more retailers follow suit – especially as the market continues to grow and prove increasingly lucrative.